Changes in subclass-specific IgG Fc glycosylation associated with the postnatal maturation of the murine immune system.

ABSTRACT: Early postnatal life is characterized by a critical time period in which the developing neonatal immune system transitions from passive immunity, induced by protective maternal antibodies, to the competence of a fully functioning immune system. The inflammatory capability of both maternal and neonatal antibodies is governed by N-linked glycosylation of the Fc region, and though this has been examined extensively in adults, there is currently little information regarding antibody glycosylation patterns during early postnatal life. To characterize the murine IgG Fc glycosylation profile during early life, we used nano-LC-ESI-Qq-TOF mass spectrometry analysis to assess subclass specific Asn-297 glycosylation patterns in the serum of BALB/c mice from 5-60 days of age. From birth to adulthood,

SUBMITTER: Barrientos G 

PROVIDER: S-EPMC7498460 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature