Long-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour.

ABSTRACT:

Purpose

Posterior fossa brain tumours (PFT) and their treatment in young children are often associated with subsequent cognitive impairment. However, reported follow-up periods rarely exceed 10 years. This study reports very long-term cognitive consequences of surviving an early childhood PFT.

Methods

62 adult survivors of a PFT, ascertained from a national register, diagnosed before 5 years of age, and a sibling control, received a single IQ assessment an average of 32 years (range 18-53) after initial diagnosis, using the Weschler Abbreviated Scale of Intelligence. Regression models were fitted to survivor-sibling pair differences on verbal and performance IQ (VIQ and PIQ) scores to investigate whether increasing time between PFT diagnosis and follow-up IQ assessment contr

SUBMITTER: Wagner AP 

PROVIDER: S-EPMC7498491 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature