Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis.

ABSTRACT: Population studies suggest that atopic dermatitis (AD) is associated with an increased risk of obesity, however a causal relationship between these two conditions remains to be established. We therefore use Mendelian randomization (MR) to evaluate whether obesity and AD are causally interlinked. We used summary statistics extracted from genome wide association studies of Body Mass Index (BMI) and AD. MR analysis was performed in both directions to establish the direction of causality between BMI and AD. We find that genetically determined increase in adiposity is associated with increased risk of AD (odds ratio of AD 1.08 [95% CI 1.01 to 1.14; p = 0.015] per unit increase in BMI). Conversely, genetically determined increased risk of AD is not associated with a higher BMI (change in BMI att

SUBMITTER: Yew YW 

PROVIDER: S-EPMC7498603 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature