Whole transcriptome approach to evaluate the effect of aluminium hydroxide in ovine encephalon.

ABSTRACT: Aluminium hydroxide adjuvants are crucial for livestock and human vaccines. Few studies have analysed their effect on the central nervous system in vivo. In this work, lambs received three different treatments of parallel subcutaneous inoculations during 16 months with aluminium-containing commercial vaccines, an equivalent dose of aluminium hydroxide or mock injections. Brain samples were sequenced by RNA-seq and miRNA-seq for the expression analysis of mRNAs, long non-coding RNAs and microRNAs and three expression comparisons were made. Although few differentially expressed genes were identified, some dysregulated genes by aluminium hydroxide alone were linked to neurological functions, the lncRNA TUNA among them, or were enriched in mitochondrial energy metabolism related functions. In

SUBMITTER: Varela-Martinez E 

PROVIDER: S-EPMC7498608 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature