High-Throughput RNA Sequencing Analysis of Plasma Samples Reveals Circulating microRNA Signatures with Biomarker Potential in Dengue Disease Progression.

ABSTRACT: The circulating microRNA (miRNA) profile has been widely used for identifying potential biomarkers against viral infections. However, data on circulating microRNA expression patterns in dengue patients are scanty. Considering the impact of severity caused by dengue infection, circulating miRNA profiles in plasma of dengue patients may prove to be valuable for developing early prognostic markers for the disease severity. Here, we described an in-depth analytical study of small RNA sequencing data obtained from the plasma of 39 dengue patients. Integrating bioinformatics and in vitro studies, we identified differentially expressed miRNAs (DEMs) (log₂ fold change ≥1.5, P < 0.05) associated with dengue disease progression. In comparing miRNA expression pattern with the

SUBMITTER: Saini J 

PROVIDER: S-EPMC7498686 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature