Targeting Ca^{2 +} Handling Proteins for the Treatment of Heart Failure and Arrhythmias.

ABSTRACT: Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-economic burden. Calcium (Ca²⁺) dysregulation is key hallmark of the failing myocardium and has long been touted as a potential therapeutic target in the treatment of a variety of cardiovascular diseases (CVD). In the heart, Ca²⁺ is essential for maintaining normal cardiac function through the generation of the cardiac action potential and its involvement in excitation contraction coupling. As such, the proteins which regulate Ca²⁺ cycling and signaling play a vital role in maintaining Ca²⁺ homeostasis. Changes to the expression levels and function of Ca²⁺-channels, pumps and associated intracellular handling proteins contribute to altered Ca

SUBMITTER: Njegic A 

PROVIDER: S-EPMC7498719 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature