Modulating endothelial adhesion and migration impacts stem cell therapies efficacy.

ABSTRACT:

Background

Limited knowledge of stem cell therapies` mechanisms of action hampers their sustainable implementation into the clinic. Specifically, the interactions of transplanted stem cells with the host vasculature and its implications for their therapeutic efficacy are not elucidated. We tested whether adhesion receptors and chemokine receptors on stem cells can be functionally modulated, and consequently if such modulation may substantially affect therapeutically relevant stem cell interactions with the host endothelium.

Methods

We investigated the effects of cationic molecule polyethylenimine (PEI) treatment with or without nanoparticles on the functions of adhesion receptors and chemokine receptors of human bone marrow-derived Mesenchymal Stem Cells (MSC). Analyses incl

SUBMITTER: Schafer R 

PROVIDER: S-EPMC7498853 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature