20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease

ABSTRACT: 20-HETE is a potent vasoconstrictor that is implicated in the regulation of blood pressure, cerebral blood flow and neuronal death following ischemia. Numerous human genetic studies have shown that inactivating variants in the cytochrome P450 enzymes that produce 20-HETE are associated with hypertension, stroke and cerebrovascular disease. However, little is known about the expression and cellular distribution of the cytochrome P450A enzymes (CYP4A) that produce 20-HETE or the newly discovered 20-HETE receptor (GPR75) in the brain. The present study examined the cell types and regions in the rat forebrain that express CYP4A and GPR75. Brain tissue slices from Sprague Dawley (SD), Dahl Salt-Sensitive (SS) and CYP4A1 transgenic rat strains, as well as cultured human cerebral pericytes and ce

SUBMITTER: Gonzalez-Fernandez E 

PROVIDER: S-EPMC7499024 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature