Staphylococcus aureus Aggregates on Orthopedic Materials under Varying Levels of Shear Stress.

ABSTRACT: Periprosthetic joint infection (PJI) occurring after artificial joint replacement is a major clinical issue requiring multiple surgeries and antibiotic interventions. Staphylococcus aureus is the bacterium most commonly responsible for PJI. Recent in vitro research has shown that staphylococcal strains rapidly form aggregates in the presence of synovial fluid (SF). We hypothesize that these aggregates provide early protection to bacteria entering the wound site, allowing them time to attach to the implant surface, leading to biofilm formation. Thus, understanding the attachment kinetics of these aggregates is critical in understanding their adhesion to various biomaterial surfaces. In this study, the number, size, and surface area coverage of aggregates as well as of single cells of S. aur

SUBMITTER: Gupta TT 

PROVIDER: S-EPMC7499028 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature