Effect of Protein Structure on Evolution of Cotranslational Folding.

ABSTRACT: Cotranslational folding depends on the folding speed and stability of the nascent protein. It remains difficult, however, to predict which proteins cotranslationally fold. Here, we simulate evolution of model proteins to investigate how native structure influences evolution of cotranslational folding. We developed a model that connects protein folding during and after translation to cellular fitness. Model proteins evolved improved folding speed and stability, with proteins adopting one of two strategies for folding quickly. Low contact order proteins evolve to fold cotranslationally. Such proteins adopt native conformations early on during the translation process, with each subsequently translated residue establishing additional native contacts. On the other hand, high contact order prote

SUBMITTER: Zhao V 

PROVIDER: S-EPMC7499064 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature