Targeted sequencing of crucial cancer causing genes of breast cancer in Saudi patients.

ABSTRACT: Breast cancer is the most common cancer among women worldwide, causing 15% of cancer-related deaths among women. Breast cancer incidence rate is increasing in most countries. In Saudi Arabia, breast cancer constitutes nearly 22% of the newly diagnosed cancer cases in women. Breast cancer incidence in the women population of Saudi Arabia is 25.9%, with 18.2% mortality. In this study, targeted sequencing of 164 selected genes was performed on germline and somatic DNA derived from the blood and tissue samples of 50 breast cancer patients using customized panel on Ion torrent platform. This study focused on the identification of genetic variations of different cancer-causing genes, raising the hope for identification of personalized prognosis. After final filtration and validation, we found pr

SUBMITTER: Alanazi M 

PROVIDER: S-EPMC7499116 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature