Tumor-derived HMGB1 induces CD62L^dim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is highly aggressive, difficult to treat and commonly develops visceral metastasis, including lung metastasis. We observed that High mobility group box 1 protein (HMGB1) was highly expressed in human TNBC and positively correlated with cancer metastasis. The hypoxic tumor environment is known to regulate HMGB1 secretion, but an understanding of the underlying mechanism by which tumor-derived HMGB1 regulates interstitial components and promotes breast cancer lung metastasis has remained elusive. The results of the present study showed that the number of CD62L^dim neutrophils, which have a strong ability to produce neutrophil extracellular traps (NETs), increased significantly in both peripheral blood and lung tissues in a mouse TNBC model and w

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7499196 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature