Monitoring PSA levels as chemical state-variables in metal-oxide memristors.

ABSTRACT: Medical interventions increasingly rely on biosensors that can provide reliable quantitative information. A longstanding bottleneck in realizing this, is various non-idealities that generate offsets and variable responses across sensors. Current mitigation strategies involve the calibration of sensors, performed in software or via auxiliary compensation circuitry thus constraining real-time operation and integration efforts. Here, we show that bio-functionalized metal-oxide memristors can be utilized for directly transducing biomarker concentration levels to discrete memory states. The introduced chemical state-variable is found to be dependent on the devices' initial resistance, with its response to chemical stimuli being more pronounced for higher resistive states. We leverage this attri

SUBMITTER: Tzouvadaki I 

PROVIDER: S-EPMC7499304 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature