Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group.

ABSTRACT:

Purpose

Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations. The overall goal of this study was to describe the genomic landscape of myeloma using deep whole-genome sequencing (WGS) and develop a model that identifies patients with long survival.

Methods

We analyzed deep WGS data from 183 newly diagnosed patients with MM treated with lenalidomide, bortezomib, and dexamethasone (RVD) alone or RVD + autologous stem cell transplant (ASCT) in the IFM/DFCI 2009 study (ClinicalTrials.gov identifier: NCT01191060). We integrated genomic markers with clinical data.

Results

We report significant variability in mutational load and processes within MM subgroups. The timeline of observed activation of mutational processes provides the basis for 2 distinct mod

SUBMITTER: Samur MK 

PROVIDER: S-EPMC7499613 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature