Cepharanthine and Curcumin inhibited mitochondrial apoptosis induced by PCV2.

ABSTRACT:

Background

Porcine circovirus type 2 (PCV2) is an immunosuppressive pathogen with high prevalence rate in pig farms. It has caused serious economic losses to the global pig industry. Due to the rapid mutation of PCV2 strain and co-infection of different genotypes, vaccination could not eradicate the infection of PCV2. It is necessary to screen and develop effective new compounds and explore their anti-apoptotic mechanism. The 13 natural compounds were purchased, with a clear plant origin, chemical structure and content and specific biological activities.

Results

The maximum no-cytotoxic concentration (MNTC) and 50% cytotoxic concentration (CC₅₀) of 13 tested compounds were obtained by the cytopathologic effect (CPE) assay and (3-(4,5-dimethyithiazol-2-yl)-2,5-diph

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7499946 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature