Dataset Information

MiRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer.

ABSTRACT:

Background

Prostate cancer is one of the most common and socially significant cancers among men. The aim of our study was to reveal changes in miRNA expression profiles associated with lymphatic dissemination in prostate cancer and to identify the most prominent miRNAs as potential prognostic markers for future studies.

Methods

High-throughput miRNA sequencing was performed for 44 prostate cancer specimens taken from Russian patients, with and without lymphatic dissemination (N1 - 20 samples; N0 - 24 samples).

Results

We found at least 18 microRNAs with differential expression between N0 and N1 sample groups: miR-182-5p, miR-183-5p, miR-96-5p, miR-25-3p, miR-93-5p, miR-7-5p, miR-615-3p, miR-10b, miR-1248 (N1-miRs; elevated expression in N1 cohort; p < 0.05); miR-1271-5p, miR-184, miR-222-3p, miR-221-5p, miR-221-3p, miR-455-3p, miR-143-5p, miR-181c-3p and miR-455-5p (N0-miRs; elevated expression in N0; p < 0.05). The expression levels of N1-miRs were highly correlated between each other (the same is applied for N0-miRs) and the expression levels of N0-miRs and N1-miRs were anti-correlated. The tumor samples can be divided into two groups depending on the expression ratio between N0-miRs and N1-miRs.

Conclusions

We found the miRNA expression signature associated with lymphatic dissemination, in particular on the Russian patient cohort. Many of these miRNAs are well-known players in either oncogenic transformation or tumor suppression. Further experimental studies with extended sampling are required to validate these results.

SUBMITTER: Pudova EA

PROVIDER: S-EPMC7500008 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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miRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer.

Pudova Elena A EA Krasnov George S GS Nyushko Kirill M KM Kobelyatskaya Anastasiya A AA Savvateeva Maria V MV Poloznikov Andrey A AA Dolotkazin Daniyar R DR Klimina Kseniya M KM Guvatova Zulfiya G ZG Simanovsky Sergey A SA Gladysh Nataliya S NS Tokarev Artemy T AT Melnikova Nataliya V NV Dmitriev Alexey A AA Alekseev Boris Y BY Kaprin Andrey D AD Kiseleva Marina V MV Snezhkina Anastasiya V AV Kudryavtseva Anna V AV

BMC medical genomics 20200918 Suppl 8

<h4>Background</h4>Prostate cancer is one of the most common and socially significant cancers among men. The aim of our study was to reveal changes in miRNA expression profiles associated with lymphatic dissemination in prostate cancer and to identify the most prominent miRNAs as potential prognostic markers for future studies.<h4>Methods</h4>High-throughput miRNA sequencing was performed for 44 prostate cancer specimens taken from Russian patients, with and without lymphatic dissemination (N1 - ...[more]

PMID: 32948204

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