3D Bioprinting of Oxygenated Cell-Laden Gelatin Methacryloyl Constructs.

ABSTRACT: Cell survival during the early stages of transplantation and before new blood vessels formation is a major challenge in translational applications of 3D bioprinted tissues. Supplementing oxygen (O₂ ) to transplanted cells via an O₂ generating source such as calcium peroxide (CPO) is an attractive approach to ensure cell viability. Calcium peroxide also produces calcium hydroxide that reduces the viscosity of bioinks, which is a limiting factor for bioprinting. Therefore, adapting this solution into 3D bioprinting is of significant importance. In this study, a gelatin methacryloyl (GelMA) bioink that is optimized in terms of pH and viscosity is developed. The improved rheological properties lead to the production of a robust bioink suitable for 3D bioprinting and contr

SUBMITTER: Erdem A 

PROVIDER: S-EPMC7500045 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature