Physical deconditioning is the common denominator in both obese and overweight subjects with nonalcoholic steatohepatitis.

ABSTRACT:

Background

Obesity and decreased physical activity mirror increasing prevalence of nonalcoholic fatty liver disease (NAFLD).

Aim

We aimed to investigate associations between aerobic fitness, anthropometrics and disease parameters in patients with nonalcoholic steatohepatitis (NASH). We hypothesised that NASH subjects have lower aerobic power and capacity than untrained, sedentary, normal subjects.

Methods

Forty subjects (60% obese, 40% overweight) with biopsy-confirmed NASH and NAFLD activity score (NAS) ≥4 were enrolled in a clinical trial where anthropometrics, laboratories, liver fat content by MRI, activity, and aerobic fitness by cycle ergometry data were obtained.

Results

NASH subjects were significantly deconditioned compared to 148 untrained, sedentary,

SUBMITTER: Argo CK 

PROVIDER: S-EPMC7500226 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature