Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.

ABSTRACT:

Objective

To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast cancer.

Design

Prospective, open label, randomised controlled clinical trial.

Setting

32 centres in 10 countries in the United Kingdom, Europe, Australia, the United States, and Canada.

Participants

2298 women aged 45 years and older with invasive ductal carcinoma up to 3.5 cm in size, cN0-N1, eligible for breast conservation and randomised before lumpectomy (1:1 ratio, blocks stratified by centre) to either risk adapted targeted intraoperative radiotherapy (TARGIT-IORT) or external beam radiotherapy (EBRT).

Interventions

Random allocation was

SUBMITTER: Vaidya JS 

PROVIDER: S-EPMC7500441 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature