Microbiome analyses of blood and tissues suggest cancer diagnostic approach.

ABSTRACT: Systematic characterization of the cancer microbiome provides the opportunity to develop techniques that exploit non-human, microorganism-derived molecules in the diagnosis of a major human disease. Following recent demonstrations that some types of cancer show substantial microbial contributions^1-10, we re-examined whole-genome and whole-transcriptome sequencing studies in The Cancer Genome Atlas¹¹ (TCGA) of 33 types of cancer from treatment-naive patients (a total of 18,116 samples) for microbial reads, and found unique microbial signatures in tissue and blood within and between most major types of cancer. These TCGA blood signatures remained predictive when applied to patients with stage Ia-IIc cancer and cancers lacking any genomic alterations currently measured o

SUBMITTER: Poore GD 

PROVIDER: S-EPMC7500457 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature