Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.

ABSTRACT: Testosterone treatment of hypogonadal men improves their hemoglobin, but the mechanism is not understood. To investigate possible mechanisms by which testosterone stimulates erythropoiesis in hypogonadal older men with unexplained or iron-deficiency anemia. The Anemia Trial of The Testosterone Trials, a placebo-controlled study in older, hypogonadal men. Twelve academic medical centers. A total of 95 hypogonadal men (testosterone < 275 ng/mL) ≥65 years with anemia (hemoglobin < 12.7 g/dL). They were classified as having unexplained (n = 58) or iron deficiency anemia (n = 37). Testosterone or placebo gel for 1 year. Markers of iron metabolism during the first 3 months of treatment. Testosterone replacement significantly (P < 0.001) increased hemoglobin in the 58 men who had unexplained anem

SUBMITTER: Artz AS 

PROVIDER: S-EPMC7500468 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature