Decline Variability of Cortical and Subcortical Regions in Aging: A Longitudinal Study.

ABSTRACT: Describing the trajectories of age-related change for different brain structures has been of interest in many recent studies. However, our knowledge regarding these trajectories and their associations is still limited due to small sample sizes and low numbers of repeated measures. For the present study, we used a large longitudinal dataset (four measurements over 4 years) comprising anatomical data from a sample of healthy older adults (N = 231 at baseline). This dataset enables us to gain new insights about volumetric cortical and subcortical changes and their associations in the context of healthy aging. Brain structure volumes were derived from T1-weighted MRI scans using FreeSurfer segmentation tools. Brain structure trajectories were fitted using mixed models and latent growth

SUBMITTER: Sele S 

PROVIDER: S-EPMC7500514 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature