Salivary and Serum Inflammatory Profiles Reflect Different Aspects of Inflammatory Bowel Disease Activity.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) can manifest both macroscopically and microscopically in the oral cavity; however, little is known about salivary changes in IBD. Therefore, this study aimed to assess salivary and circulatory inflammatory profiles in IBD and to compare their potential to reflect the presence and activity of IBD.

Methods

We measured 92 known inflammatory proteins in serum and in unstimulated and stimulated whole saliva samples from patients with IBD with active intestinal inflammation (n = 21) and matched control patients (n = 22) by proximity extension assay. Fifteen of the patients with IBD returned 10 to 12 weeks after treatment escalation for resampling.

Results

Sixty-seven of the proteins were detected in all 3 sample fluids but formed

SUBMITTER: Majster M 

PROVIDER: S-EPMC7500518 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature