Biodistribution of degradable polyanhydride particles in Aedes aegypti tissues.

ABSTRACT: Insecticide resistance poses a significant threat to the control of arthropods that transmit disease agents. Nanoparticle carriers offer exciting opportunities to expand the armamentarium of insecticides available for public health and other pests. Most chemical insecticides are delivered by contact or feeding, and from there must penetrate various biological membranes to reach target organs and kill the pest organism. Nanoparticles have been shown to improve bioactive compound navigation of such barriers in vertebrates, but have not been well-explored in arthropods. In this study, we explored the potential of polyanhydride micro- and nanoparticles (250 nm- 3 μm), labeled with rhodamine B to associate with and/or transit across insect biological barriers, including the cuticle, epithelium,

SUBMITTER: Norris EJ 

PROVIDER: S-EPMC7500644 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature