MGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.

ABSTRACT: Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived from 17 patients and age-matched and sex-matched controls. The patient group showed a striking reduction in mGluR5 signaling, manifested by decreases in Gq/11 coupling and association with PI3K and Homer compared to controls (p?

SUBMITTER: Wang HY 

PROVIDER: S-EPMC7500805 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature