Oral Nifidepine versus IV labetalol in severe preeclampsia: A randomized control trial.

ABSTRACT:

Objective

To compare oral Nifidepine and IV labetalol in terms of rapidity of BP control in severe preeclampsia.

Methods

All patients coming to Services Hospital from March 2017 to February 2019 with diagnosis of severe preeclampsia ≥ 24 weeks gestation were randomized to either receive Nifidepine or Labetalol. Primary outcome measure was time taken to control BP and number of doses required. Secondary outcome measures were side effects of drugs, APGAR score, NICU admission and perinatal mortality.

Results

Two hundred four patients were included in trial with 102 patients in each group. Labetalol took 22.6± 13.5minutes and Nifidepine took 22.09± 11.7 minutes to achieve target BP (p>0.05). Labetalol required 2.3± 1.58 doses and Nifidepine 2.2± 1.58 doses to control BP

SUBMITTER: Wasim T 

PROVIDER: S-EPMC7500996 | biostudies-literature | 2020 Sep-Oct

REPOSITORIES: biostudies-literature