Changes of trace element status during aging: results of the EPIC-Potsdam cohort study.

ABSTRACT:

Purpose

We aimed to evaluate age-dependent changes of six trace elements (TE) [manganese (Mn), iron (Fe), zinc (Zn), copper (Cu), iodine (I), and selenium (Se)] over a 20-year period.

Methods

TE concentrations were determined using repeated serum samples taken at baseline and after 20 years of follow-up from 219 healthy participants of the EPIC-Potsdam study, using inductively coupled plasma tandem mass spectrometry. For each TE, absolute and relative differences were calculated between the two time points, as well as the proportion of individuals within normal reference ranges. Interdependence between age-related TE differences was investigated using principal component analysis (PCA). Relationships between selected factors (lifestyle, sociodemographic, anthropometric facto

SUBMITTER: Baudry J 

PROVIDER: S-EPMC7501115 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature