Quantifying Postural Control in Premanifest and Manifest Huntington Disease Using Wearable Sensors.

ABSTRACT: Background. Impairments in postural control in Huntington disease (HD) have important consequences for daily functioning. This observational study systematically examined baseline postural control and the effect of sensory attenuation and sensory enhancement on postural control across the spectrum of HD. Methods. Participants (n = 39) included healthy controls and individuals in premanifest (pHD) and manifest stages (mHD) of HD. Using wearable sensors, postural control was assessed according to (1) postural set (sit vs stand), (2) sensory attenuation using clinical test of sensory integration, and (3) sensory enhancement with gaze fixation. Outcomes included sway smoothness, amplitude, and frequency. Results. Based on postural set, pHD reduced postural sway in sitting

SUBMITTER: Porciuncula F 

PROVIDER: S-EPMC7501191 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature