A missense variant in CREBRF is associated with taller stature in Samoans.

ABSTRACT:

Objectives

Studies have demonstrated that rs373863828, a missense variant in CREBRF, is associated with a number of anthropometric traits including body mass index (BMI), obesity, percent body fat, hip circumference, and abdominal circumference. Given the biological relationship between height and adiposity, we hypothesized that the effect of this variant on BMI might be due in part to an association of this variant with height.

Methods

We tested the hypothesis that minor allele of rs373863828 is associated with height in a Samoan population in two adult cohorts and in a separate cohort of children (age 5-18 years old) using linear mixed modeling.

Results

We found evidence of a strong relationship between rs373863828 and greater mean height in Samoan adults (0.77 cm g

SUBMITTER: Carlson JC 

PROVIDER: S-EPMC7501196 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature