Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes.

ABSTRACT: Ovarian cancer is an aggressive epithelial tumor that remains a major cause of cancer morbidity and mortality in women. Epigenetic alterations including DNA methylation and histone modifications are being characterized in ovarian cancer and have been functionally linked to processes involved in tumor initiation, chemotherapy resistance, cancer stem cell survival, and tumor metastasis. The epigenetic traits of cancer cells and of associated tumor microenvironment components have been shown to promote an immunosuppressive tumor milieu. However, DNA methylation and histone modifications are reversible, and therapies targeting the epigenome have been implicated in potential reinvigoration of the antitumor immunity. In this review, we provide an overview specifically of DNA methylation and hist

SUBMITTER: Matei D 

PROVIDER: S-EPMC7501210 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature