Azobenzene-based sinusoidal surface topography drives focal adhesion confinement and guides collective migration of epithelial cells.

ABSTRACT: Surface topography is a key parameter in regulating the morphology and behavior of single cells. At multicellular level, coordinated cell displacements drive many biological events such as embryonic morphogenesis. However, the effect of surface topography on collective migration of epithelium has not been studied in detail. Mastering the connection between surface features and collective cellular behaviour is highly important for novel approaches in tissue engineering and repair. Herein, we used photopatterned microtopographies on azobenzene-containing materials and showed that smooth topographical cues with proper period and orientation can efficiently orchestrate cell alignment in growing epithelium. Furthermore, the experimental system allowed us to investigate how the orientation of th

SUBMITTER: Fedele C 

PROVIDER: S-EPMC7501301 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature