Involvement of promoter/enhancers in a feedback loop to regulate human gene expression.

ABSTRACT: The study described here was undertaken to extend the observation that some transcription factors can either stimulate or suppress gene expression depending on the local environment of their DNA binding site. It is suggested that if such transcription factors also had a mechanism to sense the expression level of the gene they control, then they could create a feedback loop able to keep expression of a gene within a limited range. The transcription factor would be activating if gene expression were determined to be too low and repressing if it were too high. To test the above idea, I have examined the effect of gene expression on the ability of the transcription factor binding areas, the promoter/enhancers, to stimulate or attenuate gene expression depending on the existing expression level

SUBMITTER: Brown JC 

PROVIDER: S-EPMC7501438 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature