The regulatory role of the RANKL/RANK/OPG signaling pathway in the mechanisms of tooth eruption in patients with impacted teeth.

ABSTRACT:

Background

Tooth impaction is a common problem in orthodontic practice and in some cases accompanied by pain and pathological changes of surrounding teeth. Understanding the cellular and molecular mechanisms underlying tooth impaction allows finding the most effective orthodontic treatment for patients with impacted teeth (IT). RANK (receptor activator of NF-κB) / RANKL (RANK ligand) / OPG (osteoprotegerin) signaling pathway controls bone resorption and may be involved in the regulation of tooth eruption. The study aimed to evaluate bone remodeling based on the assessment of the RANKL/RANK/OPG status in patients with IT.

Methods

Bone samples from 18 patients (mean age 25.27 ± 3.34) were divided into 3 groups: 1 - bone tissue of healthy persons (control group); 2 - bone tissu

SUBMITTER: Brodetska L 

PROVIDER: S-EPMC7501598 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature