Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma.

ABSTRACT:

Background

Asthma is a chronic disorder of both adults and children affecting more than 300 million people heath worldwide. Diagnose and treatment for asthma, particularly in childhood asthma have always remained a great challenge because of its complex pathogenesis and multiple triggers, such as allergen, viral infection, tobacco smoke, dust, etc. It is thereby great significant to deeply investigate the transcriptome changes in asthmatic children before and after desensitization treatment, in order that we could identify potential and key mRNAs and lncRNAs which might be considered as useful RNA molecules for observing and supervising desensitization therapy for asthma, which might guide the diagnose and therapy in childhood asthma.

Methods

In the present study, we perform

SUBMITTER: Zheng P 

PROVIDER: S-EPMC7501638 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature