Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma.

ABSTRACT:

Background

Galectins (Gal) are a family of protein that bind to the β-galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis. A series of experimental and clinical evidences have been reported to support a correlation between galectin expressions and neoplastic transformation, progression and prognosis. The objective of this study was to estimate the expression of Gal-3 and Gal-9 in order to evaluate their relation to hepatocellular carcinoma (HCC) -related clinical features and their prognostic values.

Methods

We evaluated Gal-3 and Gal-9 expression in 247 HCC patients by a tissue microarray immunohistochemistry method, then analyzed the relationship between expression levels of Gal-3 and

SUBMITTER: Kong F 

PROVIDER: S-EPMC7501799 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature