Hydroxychloroquine early in pregnancy and risk of birth defects.

ABSTRACT:

Background

Hydroxychloroquine is generally considered safe in pregnancy for the treatment of rheumatic conditions, but studies have been too small to evaluate teratogenicity. Quantifying the risk of congenital malformations associated with early pregnancy exposure to hydroxychloroquine is important in both the context of its ongoing use for rheumatological disorders and its potential future use for coronavirus disease 2019 prophylaxis, for which a number of clinical trials are ongoing despite initial trials for coronavirus disease 2019 treatment having been negative.

Objective

The study objective was to evaluate the risk of major congenital malformations associated with exposure to hydroxychloroquine during the first trimester of pregnancy, the period of organogenesis.

St

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC7501839 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature