Abnormal Activations of Super-Enhancers Enhance the Carcinogenicity in Lung Adenocarcinoma.

ABSTRACT:

Background

Lung tumors and normal lung tissues show large differences in epigenetic modification which can affect the chromosome structure and expression of genes. However, the epigenetic reprogramming in lung adenocarcinoma remains unclear.

Methods and results

With the bioinformatics analysis, we found that some activated super-enhancers (SEs) only appear in lung adenocarcinoma cells, and 781 abnormal activated super-enhancers (AASEs) were found. Not only are the traditional oncogenes found to be activated by AASEs, such as MET and SLC2A1, but also some new genes were activated by AASEs, which probably contributes to the carcinogenic process in lung cancer. The enrichment analysis of the genes activated by AASEs shows that the glycolysis process and cell proli

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7501973 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature