Ontology highlight
ABSTRACT:
SUBMITTER: Thielen LA
PROVIDER: S-EPMC7501995 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Thielen Lance A LA Chen Junqin J Jing Gu G Moukha-Chafiq Omar O Xu Guanlan G Jo SeongHo S Grayson Truman B TB Lu Brian B Li Peng P Augelli-Szafran Corinne E CE Suto Mark J MJ Kanke Matt M Sethupathy Praveen P Kim Jason K JK Shalev Anath A
Cell metabolism 20200728 3
Diabetes is characterized by hyperglycemia, loss of functional islet beta cell mass, deficiency of glucose-lowering insulin, and persistent alpha cell secretion of gluconeogenic glucagon. Still, no therapies that target these underlying processes are available. We therefore performed high-throughput screening of 300,000 compounds and extensive medicinal chemistry optimization and here report the discovery of SRI-37330, an orally bioavailable, non-toxic small molecule, which effectively rescued m ...[more]