Novel approaches and current challenges with targeting the endocannabinoid system.

ABSTRACT:

Introduction

The pathophysiological relevance of the endocannabinoid system has been widely demonstrated in a variety of diseases including cancer, neurological disorders, and metabolic issues. Therefore, targeting the receptors and the endogenous machinery involved in this system can provide a successful therapeutic outcome. Ligands targeting the canonical cannabinoid receptors, CB₁ and CB₂, along with inhibitors of the endocannabinoid enzymes have been thoroughly studied in diverse disease models. In fact, phytocannabinoids such as cannabidiol or Δ⁹-tetrahydrocannabinol are currently on the market for the management of neuropathic pain due to spasticity in multiple sclerosis or seizures in children epilepsy amongst others.

Areas covered

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SUBMITTER: Morales P 

PROVIDER: S-EPMC7502221 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature