COVID-19 susceptibility: potential of ACE2 polymorphisms

ABSTRACT:

Background

Angiotensin-converting enzyme 2 (ACE2) is a metallopeptidase that primarily functions as a negative regulator of renin angiotensin system (RAS) by converting angiotensin II (Ang II) to angiotensin 1-7. Contrary to this, another RAS component, angiotensin-converting enzyme (ACE) catalyzes synthesis of Ang II from angiotensin I (Ang I) that functions as active compound in blood pressure regulation. This indicates importance of ACE/ACE2 level in regulating blood pressure by targeting Ang II. An outbreak of severe acute respiratory syndrome (SARS) highlighted the additional role of ACE2 as a receptor for SARS coronavirus (SARS-CoV) infection.

Main body of the abstract

ACE2 is a functional receptor for SARS-CoV and SARS-CoV-2. Activation of spike (S)-protein by eith

SUBMITTER: Chaudhary M 

PROVIDER: S-EPMC7502288 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature