Identification of gene modules associated with survival of diffuse large B-cell lymphoma treated with CHOP-based chemotherapy.

ABSTRACT: Diffuse Large B-cell Lymphoma (DLBCL), a heterogeneous disease, is influenced by complex network of gene interactions. Most previous studies focused on individual genes, but ignored the importance of intergenic correlations. In current study, we aimed to explore the association between gene networks and overall survival (OS) of DLBCL patients treated with CHOP-based chemotherapy (cyclophosphamide combination with doxorubicin, vincristine and prednisone). Weighted gene co-expression network analysis was conducted to obtain insights into the molecular characteristics of DLBCL. Ten co-expression gene networks (modules) were identified in training dataset (n = 470), and their associations with patients' OS after chemotherapy were tested. The results were validated in four independent datasets

SUBMITTER: Gao Y 

PROVIDER: S-EPMC7502356 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature