Depressogenic self-schemas are associated with smaller regional grey matter volume in never-depressed preadolescents.

ABSTRACT: Self-referential processing (i.e., self-schemas that guide processing of self-descriptive information) emerges early in youth, with deeper encoding of negative self-descriptors and/or shallower encoding of positive self-descriptors causally linked to depression. However, the relationship between depressogenic self-schemas and brain structure is unclear. We investigated associations between self-schemas and regional grey matter volume (GMV) in 84 never-depressed preadolescents oversampled for depression risk based on maternal depression history. Self-schemas were assessed using a Self-Referent Encoding Task (SRET) and regional GMV was indexed via voxel-based morphometry analysis of structural magnetic resonance imaging data. Youths' positive self-schemas were associated with greater regiona

SUBMITTER: Liu P 

PROVIDER: S-EPMC7502366 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature