KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report.

ABSTRACT:

Study rationale

The coexistence of KRAS and PIK3CA mutations in cells implies potential synergistic hyperactivation of the Ras/MAPK and PI3K/Akt oncogenic pathways. Therefore, it is desirable to investigate the concomitant mutations of KRAS and PIK3CA in colorectal cancer (CRC) samples and whether the concomitant mutations are associated with a poor prognosis in CRC patients.

Aim

To investigate the clinicpathological characteristics and prognostic value of concomitant mutations of KRAS and PIK3CA in CRC samples.

Methods

In this study, a total of 655 CRC patients from the Sixth Affiliated Hospital of Sun Yat-sen University were enrolled from January to December 2015. Sanger sequencing was applied to survey the mutational status of hotspot regions in the open reading fr

SUBMITTER: Luo Q 

PROVIDER: S-EPMC7502368 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature