Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics.

ABSTRACT:

Background

The prevalence of heart failure (HF) is rising with ageing population and constitutes a major health problem globally. A common complication of HF is pulmonary hypertension (PH) which negatively impacts survival. A pathophysiological association between HF and PH with tumorigenic processes has been suggested. We aimed to identify the plasma levels of, and the association between tumour-related proteins and hemodynamic improvements in patients with HF and PH due to left heart disease (LHD) before and 1-year after heart transplantation (HT).

Methods

Forty-eight tumour-related proteins were measured with proximity extension assay in plasma from 20 controls and 26 HF patients before and 1-year after HT. Patients' hemodynamics were measured with right heart catheteriza

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC7502449 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature