The Evolving Burden of Drug Use Associated Infective Endocarditis in the United States.

ABSTRACT:

Background

The rise in the number of valve operations performed for infective endocarditis (IE) due to drug use is an important manifestation of the opioid epidemic. This study characterized national trends and outcomes of valve surgery for drug use-associated IE (DU-IE).

Methods

Adults undergoing valve surgery for active IE in The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database between July 2011 and June 2018 were stratified as DU-IE and non-DU-IE. Trends and clinical profiles were analyzed. Early outcomes were assessed. The association of DU-IE with outcomes was analyzed with multivariable regression, adjusting for STS Valve Risk model covariates.

Results

There were 34,905 valve operations performed for IE, of which 33.7% were for DU-IE. DU-IE oper

SUBMITTER: Geirsson A 

PROVIDER: S-EPMC7502470 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature