The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on the Cellular Source.

ABSTRACT:

Background & aims

Calcineurin is a ubiquitously expressed central Ca²⁺-responsive signaling molecule that mediates acute pancreatitis, but little is known about its effects. We compared the effects of calcineurin expression by hematopoietic cells vs pancreas in mouse models of pancreatitis and pancreatitis-associated lung inflammation.

Methods

We performed studies with mice with hematopoietic-specific or pancreas-specific deletion of protein phosphatase 3, regulatory subunit B, alpha isoform (PPP3R1, also called CNB1), in mice with deletion of CNB1 (Cnb1^UBC△/△) and in the corresponding controls for each deletion of CNB1. Acute pancreatitis was induced in mice by administration of caerulein or high-pressure infusion of radiocontrast into biliopancreatic

SUBMITTER: Wen L 

PROVIDER: S-EPMC7502475 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature