Serotonin transporter protein in autopsied brain of chronic users of cocaine.

ABSTRACT:

Rationale

The long-held speculation that the brain serotonin system mediates some behavioral effects of the psychostimulant cocaine is supported in part by the high affinity of cocaine for the serotonin transporter (SERT) and by reports that the serotonin transporter (SERT), estimated by SERT binding, is increased in brain of human chronic cocaine users. Excessive SERT activity and consequent synaptic serotonin deficiency might cause a behavioral (e.g., mood) abnormality in chronic users of the drug.

Objective and methods

Previous studies focused on changes in SERT binding, which might not necessarily reflect changes in SERT protein. Therefore, we compared levels of SERT protein, using a quantitative Western blot procedure, in autopsied brain (striatum, cerebral cortices) of

SUBMITTER: Tong J 

PROVIDER: S-EPMC7502513 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature