Compulsive methamphetamine taking induces autophagic and apoptotic markers in the rat dorsal striatum.

ABSTRACT: Methamphetamine (METH) use disorder (MUD) is often accompanied by psychotic symptoms, cognitive deficits, and pathological changes in the brains of users. Animals that experimenters injected with drugs also show neurodegenerative changes in their brains. Recently, we have been investigating METH-induced molecular and biochemical consequences in animals that had infused themselves with METH using the drug self-administration (SA) paradigm. In that model, footshocks administered contingently help to separate rats that had already escalated their METH intake into resilient-to-drug (shock-sensitive, SS) or compulsive (shock-resistant, SR) METH takers. Herein, we used that model to test the idea that compulsive METH takers might show evidence of drug-induced autophagic changes in their brains.

SUBMITTER: Subu R 

PROVIDER: S-EPMC7502530 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature