Ontology highlight
ABSTRACT:
SUBMITTER: Dorweiler JE
PROVIDER: S-EPMC7502544 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Dorweiler Jane E JE Oddo Mitchell J MJ Lyke Douglas R DR Reilly Jacob A JA Wisniewski Brett T BT Davis Emily E EE Kuborn Abigail M AM Merrill Stephen J SJ Manogaran Anita L AL
Molecular microbiology 20200608 3
Chaperone networks are required for the shearing and generation of transmissible propagons from pre-existing prion aggregates. However, other cellular networks needed for maintaining yeast prions are largely uncharacterized. Here, we establish a novel role for actin networks in prion maintenance. The [PIN<sup>+</sup> ] prion, also known as [RNQ<sup>+</sup> ], exists as stable variants dependent upon the chaperone machinery for the transmission of propagons to daughter cells during cell division ...[more]