The actin cytoskeletal network plays a role in yeast prion transmission and contributes to prion stability.

ABSTRACT: Chaperone networks are required for the shearing and generation of transmissible propagons from pre-existing prion aggregates. However, other cellular networks needed for maintaining yeast prions are largely uncharacterized. Here, we establish a novel role for actin networks in prion maintenance. The [PIN⁺ ] prion, also known as [RNQ⁺ ], exists as stable variants dependent upon the chaperone machinery for the transmission of propagons to daughter cells during cell division and cytoplasmic transfer. Loss of the Hsp104 molecular chaperone leads to the growth of prion particles until they are too large to be transmitted. Here, we isolated a unique [PIN⁺ ] variant, which is unstable in actin mutants. This prion loss is observed over many generations, and coinci

SUBMITTER: Dorweiler JE 

PROVIDER: S-EPMC7502544 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature