A hybrid model of intercellular tension and cell-matrix mechanical interactions in a multicellular geometry.

ABSTRACT: Epithelial cells form continuous sheets of cells that exist in tensional homeostasis. Homeostasis is maintained through cell-to-cell junctions that distribute tension and balance forces between cells and their underlying matrix. Disruption of tensional homeostasis can lead to epithelial-mesenchymal transition (EMT), a transdifferentiation process in which epithelial cells adopt a mesenchymal phenotype, losing cell-cell adhesion and enhancing cellular motility. This process is critical during embryogenesis and wound healing, but is also dysregulated in many disease states. To further understand the role of intercellular tension in spatial patterning of epithelial cell monolayers, we developed a multicellular computational model of cell-cell and cell-substrate forces. This work builds on a h

SUBMITTER: Scott LE 

PROVIDER: S-EPMC7502553 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature